Thermodox

This article explains why thermodox could be very useful for liver cancer and metastasis:
http://seekingalpha.com/article/607921-celsion-is-ripe-for-a-long-position

Thermodox is a heat-activated form of doxurubin.    Combining thermodox with hyperthermia/RFA treatment could help deliver doxurubicin at higher concentration into liver metastasis (possibly kidney, pancreas)  locally.   As a result, side effect to heart is minimized while cancer gets its full of this powerful drug.

"Studies in a rabbit tumor model also showed that heat-activated ThermoDox delivered 10-fold more doxorubicin to the tumor, than conventional injections of doxorubicin. And although ThermoDox did accumulate to high levels in the kidney and spleen, it was not higher than conventional injections of doxorubicin. Finally, the 2008 Phase 1 trial for ThermoDox in liver cancer showed that an optimal dose of 50mg/m² extended the time-to-progression from 1 month to 6 months and, very importantly, the "dead zone" within the tumor kept expanding for 3 months after the radiofrequency ablation treatment, suggesting that heat-activated ThermoDox was killing the presumed chemo-resistant tumor cells with long-lasting effect. In contrast, the "dead zone" shrunk over time with radiofrequency ablation treatment alone. "