Silver makes antibiotics much more effective:
http://www.scientificamerican.com/article.cfm?id=silver-makes-antibiotics-thousands-of-times-more-effective
Osteoporosis Drug Stops Growth of Breast Cancer Cells, Even in Resistant Tumors
This is preclinical. Some interesting comments by the author of bazedoxifene study, mentions other SERD (like Faslodex) that actually tested well in early clinical trials 10 years ago, but was shut down.
"about 10 years ago our lab identified and developed another SERD that is just as effective in vitro, could be administered orally, worked great in animal models, and, when Dupont took it into a small investigator initiated trial, worked well even in patients who had progressed during therapies targeting estrogen receptor. So well, in fact, that when BMS bought Dupont and assumed that a paint company knew nothing about healthcare and closed the trial, the patients' Drs sued to keep them on the trial. BMS responded by destroying 4 million tablets." I'm trying to figure out that little bit of history.
Anti Cancer goo secreted by naked Mole Rats Pretty interesting:
CFI-400945 is applying for clinical trial:
This drug is from the same UCLA lab (Dr Slamon) that gives us Herceptin and Palbociclib. If this drug and other drugs from this UCLA Canadian Chinese partnership are any thing like Herceptin or Palbociclib, then, well, maybe i could stop writing this blog happily.
Quote from this article:
“I cannot promise you that it will work,” he said of the experimental drug, “because in advanced human cancer there are many other questions that we have not got answers to.
“But we promise you this is the beginning,” said Mak, his voice breaking with emotion. “There will be another drug that we will be filing for [approval] next year — and next year and next year — until we get this done.”
It’s taken about 100 researchers in Toronto, L.A. and China to develop CFI-400945 at a cost so far of about $40-million, said Mak, standing beside a copy of the 4,300-page application submitted to the FDA, the height of about five Toronto phone books.
That money all came from non-government sources, raised through 10 years of fundraising walks to end women’s cancers, and private and corporate donations.
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