Friday, August 9, 2013

not exciting but interesting

http://www.sciencedaily.com/releases/2013/06/130605111527.htm

Lengthening drug response 30% sounds not too bad, except when you notice that you are still talking about a couple months more time, maybe.    15 years of MBC living is still the exception, not the rule by any form.


http://www.mountsinai.org/about-us/newsroom/press-releases/blocking-sugar-intake-may-reduce-cancer-risk-or-progression-in-obese-and-diabetic-people

Multitarget drug cocktail may be the way to go.   But the number of clinical trials that needs to go through is staggering.   

Quote: Armed with three new drug targets—glucose, the Ras/Src oncogenes, and Wingless/Wnt signaling—Dr. Cagan and his team identified compounds that can block the process. 

They treated the flies with acarbose, a treatment for diabetes; a compound called AD81; and a drug called pyrvinium. Acarbose blocked sugar conversion to glucose; AD81 cut off Ras/Src and caused cell death; and pyrvinium inhibited Wingless/Wnt signaling. Taken together, this cocktail of drugs substantially reduced tumor size and progression.

“Our study shows that sugar activates oncogenes in the tumor, which then promote insulin sensitivity, meaning that the exorbitant glucose levels in the blood pour into the tumor, having nowhere else to go in the insulin-resistant body,” said Dr. Cagan. “We have identified a three-drug combination that stops this signaling activity and tumor growth in its tracks, without affecting normal cell function.”

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