PD991 or Palbociclib Receives FDA Breakthrough Designation

http://www.fiercebiotech.com/press-releases/pfizers-palbociclib-pd-0332991-receives-food-and-drug-administration-breakt

Copper Reduction for TN

If they are able to keep even 1/2 of the metastatic TNBC folks alive for a few years, that's pretty awesome:
http://weill.cornell.edu/news/releases/wcmc/wcmc_2013/02_13_13.shtml

Their clinical trial is expanding.

NeuroBlate on recurrent glioblastoma multiforme

http://www.medpagetoday.com/TheGuptaGuide/Oncology/38288

"In the first-in-man phase I study, published online in the Journal of Neurosurgery,median survival of 10 patients treated with the NeuroBlate Thermal Therapy System was 316 days."

Doubling the survival of a very aggressive brain cancer.   Could it be used for other type of brain tumor as well?   

Circulating Tumor DNA: Proof of concept

http://www.nejm.org/doi/full/10.1056/NEJMoa1213261

29/30 metastatic patient sees their CT dna above normal.   Wow!

Great Clue Mystery

Cancer, Immune system, Brain, these are arguably the 3 enduring high stake mysteries in medicine.  

I put Cancer first, because it is the one mysteries with dead bodies all over the carpet.   And thousands of characters, some are suspected ring leaders, some are accomplices, some are panicked onlookers, some are striking security guards.       

Then there are researchers, like detectives, some focus on "who dunnit", some on "how dunnit", some on "protecting the innocent and preventing carnage".    They need all the help they could get.

This new development from Minnesota implicates a well hidden ring leader that may lead to a new strategy:

http://medicalxpress.com/news/2013-02-enzyme-breast-cancer-mutations.html#jCp

While this NIH development seems to study the "how dunnit" mystery that metabolism affects cancer

http://www.nih.gov/news/health/feb2013/nci-05.htm

Interesting new development

BCO members shared these research, new approaches and fresh understanding of the puzzle that is cancer:

Gold nanoparticle in HDL used to target lymphoma cancer cells
http://www.sciencedaily.com/releases/2013/01/130121161915.htm

New understanding of how Beta blockers' effect on cancer:
http://www.sciencedaily.com/releases/2013/01/130129121843.htm

Metastasis pathways:
http://www.eurekalert.org/pub_releases/2013-01/cu-cbd011813.php
http://www.sciencedaily.com/releases/2013/01/130127134214.htm

Review article and clinical trials

http://www.asco.org/ASCOv2/Home/Education%20&%20Training/Educational%20Book/PDF%20Files/2012/zds00112000028.PDF

It mentions also BKM120 and other new drugs

http://www.dovepress.com/new-and-emerging-treatments-for-estrogen-receptor-positive-breast-canc-peer-reviewed-article-TCRM