Drug combos may be found to cure Cancer by attacking Multiple Pathways

Similar to AIDS?
http://www.ascopost.com/issues/june-25,-2014/oral-two-drug-regimen-appears-promising-in-phase-ii-trial-of-recurrent-platinum-sensitive-ovarian-cancer.aspx

Tetanus Shot Doubles Glioblastoma Life Expectancy

Working in concert with cancer targeting immunotherapy,
Tetanus Shot Doubles Glioblastoma Life Expectancy.
http://www.nbcnews.com/health/cancer/tetanus-vaccine-boosts-cancer-therapy-n321596

This is incredible and wonderful.
Firstly: this works on the brain.
Secondly: very few bloblastoma 5 year survivors.
http://virtualtrials.com/pdf/long-termsurvivalofglioblastoma.pdf

Penn and Mayo have two good immunotherapy programs for
ovarian and breast cancer.   Maybe there are other centers too.
Will dig more into it.
http://www.uphs.upenn.edu/obgyn/research/ovarian_clinical.htm

Chinese anti-malaria drug+iron

artemisinin is the drug that Chinese used to kill malaria

with 98% efficacy.   malaria like cancer cells tend to 

concentrate iron in their cells, and artemisinin completely

beats the efficacy of any western malaria drugs (70%).

Now it looks like artemisinin+iron could really kill breast

cancer too:

http://truththeory.com/2013/12/25/little-known-chinese-herb-iron-kill-98-of-cancer-cells-in-16-hours/

other anti malaria drug also are in trials for breast cancer.

http://killerboob.blogspot.com/2012/05/anti-malari...

Dasatinib Doubles PFS for ER+ women on Letrozole

http://www.news-medical.net/news/20131213/Dasatinib2bletrozole-improves-survival-for-women-with-hormone-receptor-positive-HER2-negative-metastatic-breast-cancer.aspx

http://www.forbes.com/sites/tommeyer/2013/12/16/hope-for-breast-cancer-patients-is-around-the-corner/

CDX-011 results are pretty good for triple negative MBC patients.   But still not good enough.

iSpy-2 shows 2 drugs winners

Quote:

Both drugs were tested in an unconventional mid-stage trial called I-Spy 2. The trial involves patients with cancers confined to the breast, where a cure is possible but the disease is at high risk of spreading to other parts of the body. In one of the novel features of the study, the drugs were measured on their ability to eradicate the cancer in just six months, before any surgery to remove tumors.

Veliparib, for instance, when combined with the drug carboplatin and a six-month regimen of standard chemotherapy, achieved a complete response in 52% of patients compared with 26% for patients treated with standard chemo alone, according to results presented Friday at the annual San Antonio Breast Cancer Symposium.

Typically, late-stage cancer drug studies succeed only 30% to 40% of the time, said Laura Esserman, director of the breast care center at University of California San Francisco and co-leader of I-Spy 2. Such trials can involve several thousand patients--many of whom wind up taking drugs that don't help them--and can take nearly a decade to get an answer.

...

Whether the promising results will translate into a speedier approval--or any approval at all--isn't assured. A key to the I-Spy strategy is that the FDA accepts a complete response at six months--meaning that no residual cancer cells can be detected after the tumor and lymph nodes are removed--as a surrogate for a long-term benefit. The aim is for FDA to allow a drug on the market on that basis, on the condition that follow-up research demonstrates a long-term benefit.

http://online.wsj.com/article/BT-CO-20131213-705589.html?dsk=y

Surgeon's skill at the Surgery table a Key factor of Success

Obvious, but apparently it takes 3000 year of medicine to state:

http://well.blogs.nytimes.com/2013/10/31/a-vital-measure-your-surgeons-skill/