PD-991 may qualify for the Fast track

Pfizer wants to fast track this miracle drug based on strong phase II results:
http://www.pfizer.com/files/news/asco/pd_0332991_cdk_4_6_inhibitor_fact_sheet.pdf
http://www.bloomberg.com/news/2013-01-10/pfizer-may-push-5-billion-breast-cancer-hope-for-ruling.html

There are more drugs in the pipeline that is based on the same principle from other drug makers

http://www.kantarhealth.com/blog/oncology/stephanie-hawthorne/2012/12/06/CDK_Inhibition_The_Next_Big_Thing_in_ER_Breast_Cancer_Impresses_at_SABCS_2012

Last December news about PD-991:  26 month PFS (PD-991) compared with <10 months PFS with Femara alone
http://killerboob.blogspot.com/2012/12/pd-991-with-femara.html

Foundation Medicine Got More from Bill Gates

Not full-genome sequencing.  but much better than Oncotype or Mammotype.   Costs similar around $5k.

Complete Genomics is another pioneer complete sequencer

http://www.boston.com/businessupdates/2013/01/08/bill-gates-invests-foundation-medicine-which-uses-genome-data-for-cancer-diagnostics/BtipX6STIA5prjmrjJkHzI/story.html

A new angle of attack from Japan via T-cell

T-cell attack from Japan

Drug to prevent blood clots

Considering how many BC patients actually die of blood clots, this new drug is very interesting:

http://www.bloomberg.com/news/2012-12-08/blood-thinner-from-pfizer-bristol-myers-blocks-leg-clots.html

What cost in 2 months delay in diagnosing/treating Advanced Breast Cancer?

This paper gives us some idea:

Waiting ≥ 60 days to initiate treatment was associated with a significant 66% and 85% increased risk of overall and breast cancer–related death, respectively, among late-stage patients

http://jco.ascopubs.org/content/early/2012/11/16/JCO.2012.39.7695.abstract

PD-991 with Femara

CDK inhibitor along with femara giving 26months PFS instead of <10 months PFS with femara alone.   Phase II trial only.   But still impressive.

http://www.fool.com/investing/businesswire/2012/12/05/pfizer-presents-phase-2-data-showing-investigation.aspx

http://erc.endocrinology-journals.org/content/18/4/C19.long

TEDMED 20 greatest medical challenges

There's one item that includes Cancer as "Management of Chronic Conditions".   I don't think majority of stage 4 aggressive breast cancer is really manageable yet, certainly not chronic in the way diabetes and heart disease patients have decades to expect.

Here's the list:

www.tedmed.com/greatchallenges

Don't get me wrong, I love TED, and would probably love TEDMED too.  But apparently cancer cure is NOT very challenging for them.